Toxicology International (Formerly Indian Journal of Toxicology)

Nagaraju Bandaru ¹, A. Narayana Rao ¹, Yasho Deepika ², Alekhya Ketha ³, Daveedu Thathipudi ⁴, N. Sri Laxmi ¹

Affiliations
1 College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Guntur - 522502, Andhra Pradesh, IN
2 Department of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Hyderabad - 500088, Telangana, IN
3 Bharat Institute of Technology-Pharmacy, Mangalpally, Hyderabad - 501510, Telangana, IN
4 Department of Biotechnology, Vikarma Simhapuri University, Nellore – 524320, Andhra Pradesh, IN

Abstract

The Fraction from Methanolic extract whole plant of Biophytum reinwardtii (HEMBR) is traditionally used in the treatment of diabetes. Rats were treated with a standardized dose of Dexamethasone for 14 days and the effect of HEMBR at the doses of 50 and 100 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD and catalase), and body weight were observed. HEMBR showed a significant decrease in plasma glucose and serum triglyceride levels (p < 0.01) at the dose of 50 and 100 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes, GSH, SOD, and catalase were significantly increased (p < 0.01). Hence it can be concluded that Biophytum reinwardtii may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.

Keywords

Antioxidants, Diabetes, Fraction, Insulin, Resistance

Full Text